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Magnetic Technology
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  • rapid separations
  • reliable and reproducible
  • simplifies protocols
  • cost effective
  • eliminates tedious centrifugation and chromatography steps
  • allows for single tube assays
    • eliminates potential sample loss
    • run simultaneous samples
  • gentler than centrifugation
    • eliminates shear forces
    • minimizes trapping of undesired products
  • Compatible with microplates for high throughput

How Magnetic Technology Works

Advantages of Magnetic Technology

Magnetic technology provides a rapid, reliable and reproducible means for separation and isolation of biomolecules. Magnetic Porous Glass (MPG)1 products for magnetic separations are simple to use and cost effective. Use of MPG Products eliminates the need for centrifugation and column chromatography.

Magnetic separations offer the ability to process your samples in a single tube as illustrated in the diagram above. This single tube approach eliminates potential sample loss during tube transfers required in other separation methods. Processing your sample in a single tube also makes it simpler to run simultaneous samples. For high throughput applications, the process can be conducted in microplates. The magnetic properties of the particles enable concentration of target molecules as opposed to dilution of target molecules that occurs with column chromatography.

The gentler nature of a magnetic separation eliminates shear forces, which occur with centrifugation, preventing possible damage to RNA and DNA. This gentler separation technique also minimizes trapping of undesired products associated with other separation methods.

Particle Characteristics

MPG is a spheroidal, totally porous borosilicate glass particle embedded with superparamagnetic iron oxide. MPG is made through a proprietary, patented process using Controlled Pore Glass (CPG)2. MPG has similar properties to CPG providing the same advantages as this glass matrix. The porosity of MPG provides a large surface area which results in a high capacity for ligand binding. The surface of MPG may be easily derivatized to produce various functional groups by using appropriate silanes. MPG is hydrophilic and can be dried or frozen making long-term storage of immobilized biomolecules a reality. Dried MPG can be easily resuspended in liquid without the problem of irreversible aggregation. MPG is heat-stable and amenable to temperature cycling reactions as in the Polymerase Chain Reaction. MPG is also inert to solvents.

Nominal Particle Size 5 Micrometers
Nominal Pore Diameter 50 nm (500 Angstrom)
Nominal Surface Area 60 m2/gram
Density 2.5 g/ml
Composition porous borosilicate glass with iron oxide
Magnetization Type superparamagnetic (no magnetic memory)
Number of Particles 4-6 x 106 particles/mg

1MPG is a registered trademark owned by EMD Millipore Corporation and licensed by PureBiotech, LLC.

2Patents 5601979, 5610274, and 5734020 owned by EMD Millipore Corporation and licensed by PureBiotech, LLC.

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